Cognitive Performance
Cognitive & Mood Support
It’s often assumed that brain aging is inevitable, but many of the changes we associate with cognitive decline—like slower memory recall, poor focus, and low mood—are influenced by biological factors that can be supported. Carnosine, a naturally occurring dipeptide, plays a multifaceted role in brain health, helping to preserve cognitive function and mood stability through antioxidant, pH-buffering, and neuroprotective mechanisms.
While often thought of as a muscle health nutrient, carnosine’s influence extends deep into the brain. In aging individuals, increased oxidative stress and reduced neuroplasticity can impair cognition and lead to emotional instability. Clinical research shows that β-alanine supplementation—which boosts carnosine levels in the brain—can help maintain mental clarity, reduce stress, and even improve brain tissue structure.
Key Findings
- A 10-week human study in adults 70+ found significantly improved cognitive function and reduced depression scores in those taking β-alanine compared to placebo.
- Neuroimaging showed enhanced integrity in the hippocampus and amygdala—areas involved in memory and emotion regulation.
- Additional studies using carnosine and anserine observed improvements in memory, mental energy, and white matter structure.
Mechanisms of Action
Neurotrophic Activation
Enhances expression of brain-derived neurotrophic factor (BDNF), a critical regulator of neuroplasticity, memory, and emotional resilience.
Neuroinflammation Modulation
Reduces glial fibrillary acidic protein (GFAP), a marker of astrocyte activation and neuroinflammation, contributing to a healthier, more stable neural environment.
Neurotransmitter and Stress Axis Support
Influences neurotransmitter activity and stress-response pathways, contributing to improved emotional balance and reduced anxiety-like behaviors
Cellular Energy Optimization
Preserves mitochondrial integrity and function, ensuring efficient energy production required for cognitive performance and mood regulation.
Oxidative Stress Defense and pH Stability
Acts as an antioxidant and pH buffer, protecting brain cells from oxidative damage and maintaining optimal neuronal function.