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Scientific Studies

A Comparative Pharmacokinetic Assessment of TriBsyn™

Study Highlights:

  • TriBsyn™ is an encapsulated low-dose β-alanine complex.
  • TriBsyn™ increased plasma β-alanine 4.5-fold compared to conventional β-alanine.
  • TriBsyn™ achieved high plasma concentrations without the sensation of paresthesia.

Adequate availability of β-alanine is critical for maintaining health, protecting the body from toxins, and promoting longevity. High oral doses of β-alanine are often associated with uncomfortable symptoms of paresthesia, discouraging adherence to supplementation. This study aimed to evaluate the bioavailability, pharmacokinetics, and tolerability of a 400 mg Hydro Oleo encapsulated β-alanine complex (TriBsyn™) specifically designed to reduce paresthesia.

A randomized, double-blind, single-dose, three-treatment, three-way crossover oral bioavailability study was conducted in healthy older adults under fasting conditions. The study compared TriBsyn™ with low (400 mg) and high (1200 mg) doses of conventional β-alanine. TriBsyn™ (400 mg) achieved a nearly 4.5-fold and 1.3-fold increase in circulating concentrations compared to 400 mg and 1200 mg of conventional β-alanine, respectively.

Importantly, no adverse effects, including paresthesia, were observed despite the higher plasma concentrations. The Hydro Oleo technology facilitated the controlled release of β-alanine, ensuring enhanced bioavailability and tolerability. This innovative β-alanine complex demonstrates a safe, effective, and sensory-friendly approach to improving β-alanine absorption, particularly for older adults aiming to maintain good health.

Click here to explore the detailed findings of the study.

Sreeraj Gopi, Augustine Amalraj, Di Tan, Guru Ramanathan. A comparative pharmacokinetic assessment of an innovative bioavailable Hydro-Oleo β-alanine complex with conventional β-alanine: A randomized double-blind, single dose, three-treatment, three-way crossover oral bioavailability study in healthy aged-human adults under fasting conditions, Food Hydrocolloids for Health. 2025 Mar 5, 100208, ISSN 2667-0259. https://doi.org/10.1016/j.fhfh.2025.100208.

Additional Science Behind TriBsyn™

  1. Ostfeld I, Ben-Zeev T, Zamir A, Levi C, Gepner Y, Springer S, Hoffman JR. Role of β-Alanine Supplementation on Cognitive Function, Mood, and Physical Function in Older Adults; Double-Blind Randomized Controlled Study. Nutrients. 2023 Feb 12;15(4):923. <span”>doi: 10.3390/nu15040923. PMID: 36839281; PMCID: PMC9960300.
  1. Furst T, Massaro A, Miller C, Williams BT, LaMacchia ZM, Horvath PJ. β-Alanine supplementation increased physical performance and improved executive function following endurance exercise in middle aged individuals. J Int Soc Sports Nutr. 2018 Jul 11;15(1):32. doi: 10.1186/s12970-018-0238-7. PMID: 29996843; PMCID: PMC6042354.
  1. Ghodsi R, Kheirouri S. Carnosine and advanced glycation end products: a systematic review. Amino Acids. 2018 Sep;50(9):1177-1186. doi: 10.1007/s00726-018-2592-9. Epub 2018 Jun 1. PMID: 29858687.
  1. Baye E, Menon K, de Courten MP, Earnest A, Cameron J, de Courten B. Does supplementation with carnosine improve cardiometabolic health and cognitive function in patients with pre-diabetes and type 2 diabetes? study protocol for a randomised, double-blind, placebo-controlled trial. BMJ Open. 2017 Sep 1;7(9):e017691. doi: 10.1136/bmjopen-2017-017691. PMID: 28864708; PMCID: PMC5588946.
  1. Tallon MJ, Harris RC, Maffulli N, Tarnopolsky MA. Carnosine, taurine and enzyme activities of human skeletal muscle fibres from elderly subjects with osteoarthritis and young moderately active subjects. Biogerontology. 2007 Apr;8(2):129-37. doi: 10.1007/s10522-006-9038-6. Epub 2006 Sep 12. PMID: 16967207.
  1. Caruso G, Di Pietro L, Cardaci V, Maugeri S, Caraci F. The therapeutic potential of carnosine: Focus on cellular and molecular mechanisms. Curr Res Pharmacol Drug Discov. 2023 Mar 7;4:100153. doi: 10.1016/j.crphar.2023.100153. PMID: 37441273; PMCID: PMC10333684.
  1. Everaert I, Mooyaart A, Baguet A, Zutinic A, Baelde H, Achten E, Taes Y, De Heer E, Derave W. Vegetarianism, female gender and increasing age, but not CNDP1 genotype, are associated with reduced muscle carnosine levels in humans. Amino Acids. 2011 Apr;40(4):1221-9. doi: 10.1007/s00726-010-0749-2. Epub 2010 Sep 24. PMID: 20865290.
  1. Hipkiss AR. Would carnosine or a carnivorous diet help suppress aging and associated pathologies? Ann N Y Acad Sci. 2006 May;1067:369-74. doi: 10.1196/annals.1354.052. PMID: 16804013.

9. Derave, W., De Courten, B. & Baba, S.P. An update on carnosine and anserine research. Amino Acids 51, 1–4 (2019). https://doi.org/10.1007/s00726-018-02689-9