Science
What is TriBsyn™
TriBsyn™ is a carnosine booster derived from CarnoSyn® beta-alanine and formulated with Hydro Oleo technology. This patent-pending formulation provides higher bioavailability and higher potency, enabling efficacious dosages at lower volumes while effectively eliminating paresthesia. TriBsyn™ is formulated to improve particle uniformity, flowability, stability, and reduce clumping.
Why TriBsyn™ is the Best Carnosine Booster
As humans age, carnosine levels in both muscle and brain tissues decline progressively, leading to a cascade of physiological effects. This reduction in carnosine begins as early as the age of 30 and correlates with a decline in key life functions such as cognitive performance, muscle endurance, and the body’s ability to buffer lactic acid during physical exertion. Studies have demonstrated a 16% decrease in muscle carnosine levels between young adults (19-30 years) and middle-aged adults (31-50 years) (Everaert, 2011). In older adults (65-80 years), muscle carnosine levels drop by a striking 47%, contributing to a 7% reduction in muscle buffering capacity—a key factor in muscle performance (Tallon, 2007). These age-related declines can severely impact both physical and cognitive health.
Since beta-alanine is the rate-limiting factor in carnosine synthesis, our bodies demand more as we get older. Unfortunately, maintaining adequate carnosine levels can be challenging due to dietary restrictions (e.g., vegetarianism), aging, and stress (Johnson, 1992; Tallon, 2007; Everaert, 2011); and direct carnosine supplements suffer from the lack of efficiency, high cost per dose and unnecessary added ingredients.
This is where TriBsyn™ emerged as the clinically proven solution to boosting carnosine levels, delivering superior bioavailability, over four times the beta-alanine levels compared to conventional beta-alanine, and thus facilitating enhanced carnosine synthesis. Furthermore, TriBsyn™ exhibited a longer half-life compared to conventional beta-alanine, indicating a different release profile.
The Hydro Oleo Advantage
What sets TriBsyn™ apart from traditional beta-alanine formulations is its ability to maximize bioavailability while minimizing the unpleasant side effects often associated with beta-alanine, such as paresthesia—the tingling sensation caused by high oral doses. In a double-blind, randomized clinical study, TriBsyn™ not only improved bioavailability but also addressed the common challenge of paresthesia associated with conventional beta-alanine supplements.
Using metrics such as the Visual Analogue Score (VAS) and Qualitative Light Symptoms Inventory (QLSI), sensory side effects were assessed. No paresthesia or adverse effects were reported in the TriBsyn™ group, while the conventional beta-alanine groups exhibited increasing paresthesia with dose. TriBsyn™ (400 mg beta-alanine) recorded a VAS score of 0.62 (indicating almost absent symptoms), whereas conventional β-alanine (400 mg) and conventional β-alanine (1200 mg) scored 2.02 and 4.01 respectively. These results highlight the reduced sensory discomfort in the TriBsyn™ group, despite its higher bioavailability.
Bioavailability Matters: Greater Benefits for Mitochondrial, Muscle and Brain Health
The combination of intestinal lymphatic and portal vein absorption ensures that TriBsyn™ delivers significantly higher bioavailability than traditional beta-alanine supplements. This translates into greater levels of beta-alanine in the bloodstream, leading to more efficient production of carnosine in both muscle and brain tissues. As a result, users experience enhanced muscle endurance, improved physical performance, mitochondria protection from oxidative damage and carbonyl stress, and neuroprotection for brain health.
Dual Absorption Mechanisms: Intestinal Lymphatic System and Portal Vein
1. Absorption via the Intestinal Lymphatic System:
Hydro Oleo technology creates micelles—tiny lipid-based particles that encapsulate beta-alanine, making it easier for the compound to pass through the lipid-rich lymphatic system. This absorption pathway bypasses first-pass liver metabolism, which often reduces the bioavailability of many oral supplements. By entering systemic circulation directly through the lymphatic vessels, TriBsyn™ preserves a higher percentage of beta-alanine, ensuring sustained and elevated plasma levels.
2. Absorption via the Portal Vein:
A portion of TriBsyn™ beta-alanine is also absorbed through the portal vein, which transports it to the liver after initial absorption in the intestines. However, Hydro Oleo technology enables a greater proportion of beta-alanine to remain intact before it reaches the liver, minimizing its breakdown during the metabolic process and ensuring more beta-alanine enters systemic circulation.
This dual absorption strategy—combining lymphatic and gastrointestinal routes—leads to enhanced bioavailability and allows TriBsyn™ to deliver beta-alanine efficiently and consistently to muscles and the brain.